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Trimester-specific hormone support can sustain pregnancy in some cases, under obstetric care to time initiation and safe discontinuation.

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Weight changes may occur with hormone therapy, influenced by metabolism, fluid balance, and lifestyle; nutrition support can help.

Local vaginal estrogen may relieve dryness, discomfort, and recurrent UTIs with minimal systemic absorption compared to systemic hormone options.

Genetic thrombophilia may influence hormone choices; screening is considered in those with strong personal or family clot history.

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